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Elisabeth Gantt
Distinguished University Professor
Member, National Academy of Sciences, U.S.A.
Ph.D., Northwestern University, 1963
Telephone: (301) 405-1649
Fax: (301) 314-9489
E-mail:
egantt@umd.edu
Research Interests: Plant Cell and Molecular Biology, Plant Physiology
Carotenoids play essential roles in protecting organisms against potential
lethal photo-oxidative damage. In photosynthesis they function in harvesting
light for photosynthesis, but also in the dissipation of energy under conditions
of excess light. The biosynthetic pathway of carotenoids in oxygen-evolving
plants is being studied in photosynthetic microalgae as model systems.
Molecular probes for genes encoding several enzymes in the carotenoid biosynthetic
pathway are being used in studying the expression of genes (phytoene synthase,
phytoene desaturase, and lycopene cyclase) during the induction and accumulation
of carotenoid pigments in photosynthetic microalgae that are hyperaccumulators
of carotenoids under environmental stress conditions.
Success of photosynthetic organisms in natural habitats is dependent
upon the organisms' ability to adjust to varying environmental conditions.
The uniqueness of the photosynthetic pigment complexes in red algae is
being studied prompted by our recent finding of chlorophyll- binding proteins
similar to those of green plants. We are studying the structure, function,
regulation, and biosynthesis of the complex using immunological, molecular,
and biochemical approaches.
Recent Publications:
Sun, Z., F.X. Cunningham, and E. Gantt. 1998. Differential expression of two
isopentenyl pyrophosphate isomerases and enhanced carotenoid accumulation in
a unicellular chlorophyte. Proc. Natl. Acad. Sci. (USA) 95: 11482-11488.
Durnford, D.G., J.A. Deane, S. Tan, G.I. McFadden, E. Gantt, and B.R. Green.
1999. Phylogenetic assessment of the eukaryotic light-harvesting antenna proteins,
with implications for plastid evolution. J. Mol. Evol. 48: 59-68.
Grabowski, B., S. Tan, F.X. Cunningham, and E. Gantt. 2000. Characterization
of the Porphyridium cruentum Chl a-binding LHC by in vitro reconstitution: LHCaR1
binds 8 Chl a molecules and proportionately more carotenoids than CAB proteins.
Photosyn. Res. 63: 85-96.
Cunningham, F.X., and E. Gantt. 2000. Identification of multi-gene families
encoding isopentenyl diphosphate isomerase in plants by heterologous complementation
in Escherichia coli. Plant and Cell Physiol. 41: 119-123.
Ershov, Y., R.R. Gantt, F.X. Cunningham, and E. Gantt. 2000. Isopentenyl diphosphate
isomerase deficiency in Synechocystis sp. strain PCC6803. FEBS Letters.
473: 337-340.
Cunningham, F.X., T. Lafond, and E. Gantt. 2000. A possible role for LYTB in
the non- mevalonate pathway of isoprenoid biosynthesis. J. Bacteriol.
182: 5841-5848.
Grabowski, B., F.X. Cunningham, Jr., and E. Gantt. 2001. Chlorophyll and carotenoid
binding in a simple red algal LHC crosses phylogenetic lines. Proc. Natl.
Acad. Sci. (USA) 98: 2911-2916.
Cunningham, F.X., Jr. and E. Gantt. 2001. One ring or two? Determination of
ring number in carotenoids by lycopene -cyclase. Proc. Natl. Acad. Sci. (USA)
98: 2908-2910. | |