Date Lecture  Topic      Text Readings
CELLULAR CHEMISTRY AND MACROMOLECULES
8/29 1 Introduction: Historical Overview                                               2–13
8/31 2 Scientific Units and Review of Cellular Chemistry                      17–27
9/5 3 Chemical Bonds, Functional Groups, and Organic Molecules       17–27
9/7 4 Macromolecules                                                                       27–74
9/10 5 Proteins                                                                                 27–74
9/12 6 Methods of Microscopy                                                         817–845
9/14 7 Review: Cells and Organelles                                                  78–104
9/17 8 Bioenergetics, Reaction, Diffusion                                           110–130
9/19 9 Enzymes                                                                               134–159
9/21 10 Enzymes                                                                             134–159

MEMBRANES AND CELLULAR TRANSPORT
9/24 11 Membranes: Composition and Structure                                24–27, 86–88, 164–171

9/26  EXAM I: Lectures 1–10 (100 pts)

9/28 12 Membranes: Physical Properties and Proteins                       164–195
10/1 13 Introduction to Cellular Transport                                          201–228
10/3 14 Membrane Transport Systems                                             203–228
10/5 15 Membrane Potential and Electrochemical Equilibrium             232–240
10/8 16 Membrane Channels                                                           240–243

CELLULAR COMMUNICATIONS
10/10 27 Electrical Excitability and Action Potentials                          243–250
10/12 18 Synaptic Transmission                                                       251–261
10/15 19 Receptors and Signal Transduction                                    266–294
10/17 20 Intracellular Messengers                                                   266–294
10/19 21 Regulation of Cell Function by Intracellular Messengers       266–294
10/22 22 Extracellular Matrix and Cell–Cell Junctions                         299–323

10/24  EXAM II: Lectures 11–20 (100 pts)

METABOLISM AND PHOTOSYNTHESIS
10/26 23 Glycolysis and Fermentation                                              377–400
10/29 24 Aerobic Respiration                                                           405–444
10/31 25 Photosynthesis I                                                                451–468
11/2 26 Photosynthesis II                                                                 469–485

CELL MOTILITY
11/5 27 The Cytoskeleton                                                                 752–780
11/7 28 Microtubules and Their Assembly                                          754–765
11/9 29 Microtubule–Based Motility                                                   781–789
11/12 30 Microfilaments and Interaction of Actin–Myosin                    766–770, 789–811
11/14 31 Muscle Contraction & Regulation of Muscle Tension             791–803

11/16  EXAM III: Lectures 21–31 (100 pts)

PROTEIN SYNTHESIS, SORTING, AND ORGANELLE BIOGENESIS
11/19 32 Synthesis of Proteins                                                          670–684
11/21 33 Synthesis of Proteins                                                          670–684

11/23  THANKSGIVING HOLIDAY

11/26 34 Sorting, Glycosylation, and Posttranslational Modification      684–696
11/28 35 Sorting, Glycosylation, and Posttranslational Modification      684–696
11/30 36 Endoplasmic Reticulum, Exocytosis, and Endocytosis            329–369
12/3 37 Endoplasmic Reticulum, Lysosomes, and Vesicles                  329–369

 THE CELL CYCLE
12/5 38 The Cell Cycle                                                                       554–564
12/7 39 Regulation of the Cell Cycle                                                    564–573
12/10 40 Cellular Aspects of Cancer                                                    573–582

12/18  FINAL EXAMINATION: 10:30 AM–12:30 PM in BPS–1240 (200 pts)
Lectures 32–40,   80 pts
Lectures   1–31, 120 pts
 

DR. PAYNE’S LABORATORY SCHEDULE (TENTATIVE)

Dates     Exercise
Aug. 27–31  No Labs this Week
Sept. 3–7  No Labs this Week
Sept. 10–14  Introduction: How to write a laboratory report
Basics of Lab Procedures
Sept. 17–21  Chemotaxis of Tetrahymena to Opiates
Sept. 24–28  Protein Separation
Protein Structure and Function
Oct. 1–5  Kinetic Analysis of Trypsin Activity
Oct. 8–12  Introduction to Radioisotopes
Oct. 15–19  Amino Acid Transport I
Oct. 22–26  Amino Acid Transport II
Oct. 29–Nov. 2 Electrical Potential Across Ion Selective Membranes
Nov. 5–9  Nervous System CD-ROM
Nov. 12–16  Microscopic Examination of Cells
Nov. 19–23  Thanksgiving Break: No Labs this Week
Nov. 26–30  Microtubules: Structure and Function
Dec. 3–7  Muscle CD-ROM/ Muscle Physiology CD-ROM

LABORATORY ASSIGNMENTS (TENTATIVE)

Laboratory   Assignment   Due Date   Points
Lab Procedures   Problems   Sept. 17–21   10 pts.
Chemotaxis   Results    Sept. 24–28   10 pts.
Protein Separation  Figures and Legends  Oct. 1–5   10 pts.
Enzyme Kinetics  Full Laboratory Report Oct. 8–12   30 pts.
Amino Acid Transport Full Laboratory Report Nov. 5–9   40 pts.
Electrical Potentials  Data Tables   Nov. 12–16   10 pts.
Nervous System CD  Questions   Nov. 26–30   10 pts.
Microtubules   Full Laboratory Report Dec. 3–7   40 pts.
Muscle CD   Questions   No Later than Dec 11  10 pts.
Muscle Physiology CD Questions   No Later than Dec 11  10 pts.
Quizzes/Participation/Presentations        20 pts.
Total: 200 pts.
 

Please note that one laboratory exercise/demonstration requires the use of animals. We have reduced the number of animals used by modifying procedures and introducing computer simulations into the laboratory. However, certain key objectives of the course cannot be accomplished without utilizing animal tissues.  We adhere to Federal guidelines and insist upon humane treatment of animals at all times. If you have a problem with this approach for religious, ethical, or personal reasons, please see a member of the course staff immediately.
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POLICIES AND GRADING FOR BSCI 230

Prerequisites:  BIOL (BSCI) 105 & CHEM 103. Successful completion of these courses has been shown to be a good indicator of performance in BSCI 230. Please do not ask to be allowed to take either or both of these courses together with BSCI 230. Permission will be denied.

Textbook: The World of the Cell, (4th ed.) Benjamin/Cummings Publishing Co., Reading, MA., 2000. Becker, W.M., L. J. Kleinsmith, and J. Hardin.

Lectures: Attendance at lecture is optional but highly recommended. All exams will be based on the lectures and text readings. You are advised to take your own notes during class.

We plan to tape all the lectures, and copies will be available for student use in the Nonprint Media Center, Rm. 4210, Hornbake Library. Occasionally, a lecture tape will not be available due to problems with the recorder or the microphone. You must request a tape by the course number (BSCI 230) and the date of the lecture. It usually takes two working days to copy a lecture tape for distribution. History has shown that students relying on lecture tapes do not fare well! Use these tapes as a lecture supplement, not as a substitute!

Lecture notes obtained from note taking services are not produced by the course staff, which is hereby absolved from any responsibility for their accuracy. Any error in these notes cannot be used as an argument for a grade change on an exam. Naturally, whether you decide to buy these notes or not is totally up to you.

Work Missed Because of Absence: Absences caused by religious observances or participation in a University activity at the request of University authorities may be excused if the GTA (for laboratory matters only!) or your lecturer is notified of the conflict ahead of time. Absences caused by illness may be excused if a verifiable letter from a physician indicating the nature of the illness and the necessity of absence is provided. A note from the Health Center stating that you were “seen” on a particular date is NOT sufficient. Refer to the Undergraduate Catalog for a complete description of University policy.

Students who miss a scheduled examination for any of the above reasons should request and will be given the opportunity to take a make?up examination covering the same material. You must present a valid, documented excuse for missing a scheduled lecture examination as described above. After contacting your lecturer, presenting your documentation, and securing his/her approval, you should plan on taking the make?up examination at the date and location announced in class.

Examinations: There will be three 100-point examinations and a final, cumulative examination worth 200 points. Lab work will count a total of 200 points.

The Final Examination for Dr. Payne has been scheduled by the University for:
Tuesday, December 18, 2001; 10:30 AM–12:30 PM in BPS-1240.

Regrade Policy: Regrades in this course will be rare. Before even contemplating submitting your exam for a regrade, you should carefully review the posted key. If you feel that a question was graded incorrectly, you should then discuss your examination with your GTA. If your GTA deems that a regrade is likely, attach a typewritten note to the exam justifying your request and give the exam to Dr. Payne. Regrades must be submitted within ONE WEEK of being returned to the class. Exams submitted after the deadline will not be considered. Your lecturer will review the entire exam and either endorse or not endorse the change. Following review, points may be added or subtracted, or there may be no change in the grade. This judgment is final.

Optional Discussion Sections: Several former BSCI 230 students have graciously volunteered to conduct weekly 50-min review sessions! These sessions are OPTIONAL and may be taken without risk to your grade if you attend faithfully and make some effort to keep up with the material. Students in these sessions will be graded on the basis of 750 total points (vs. 700 points; see below). Simply by attending and participating, you have every chance of learning more and improving your grade. Sign up forms will be available beginning the first week of the course in the hallway outside the teaching laboratory. Discussions will begin the week of September 10, 2001. You will have a 2-week period to try out the sessions. After signing up, you may drop out at any time during these two weeks. If you remain in the discussion section beyond September 23, 2001, you will be graded on the basis of 750 points and be expected to attend and participate. Again, the only way to really mess this up is by not attending!

Grades:
Lecture: 71% (500 points) Laboratory: 29% (200 points)
Total  700 points
Grade of  A+ = 660–700 points
A   = 640–659 points
A– = 620–639 points

B+ = 596–619 points
B   = 573–595 points
B– = 550–572 points

C+ = 526–549 points
C   = 503–525 points
C– = 480–502 points

D+ = 460–479 points
D   = 440–459 points
D– = 420–439 points

F   = 0–419 points

For those in Discussion Sections (50 additional possible points = 750 total points)

Grade of  A+ = 707–750 points
A   = 686–706 points
A– = 664–685 points
 

B+ = 639–663 points
B   = 614–638 points
B– = 589–613 points

C+ = 564–588 points
C   = 539–563 points
C– = 514–538 points

D+ = 493–513 points
D   = 471–492 points
D– = 450–470 points

F   = 0–449 points

You either have the points or you don't. The course staff fully expects that these numbers will stand throughout the course. No changes in this scheme will even be contemplated before all the grades are in. Don’t even ask!!

Academic Honesty: The university has approved a Code of Academic Integrity. The Code prohibits students from cheating on exams, plagiarizing papers, submitting the same paper for credit in two courses without authorization, buying papers, submitting fraudulent documents, and forging signatures. The University Senate requires that students include the following signed statement on each examination or assignment: “I pledge on my honor that I have not given or received any unauthorized assistance on this examination (or assignment).”

Please review the university policies on academic integrity at the following address:

www.inform.umd.edu/CampusInfo/Departments/jpo/code_acinteg.html.

For Students having Academic Difficulties: If you are experience difficulties keeping up with the academic demands of this course, contact the Learning Assistance Service, 2201 Shoemaker Building (301/314-7693). Their educational counselors can help with time management, reading, note-taking, and exam-preparation skills.

Appointments: Communication is essential: We must hear your comments, criticisms, questions, etc. Feel free to meet with us to discuss course-related issues. Your GTA will also have time to discuss both lecture and laboratory material with you.

A computer listserv (Cellnet) will be set up on the campus e-mail network in order that students and course staff can communicate with one another. All you will need to receive these important communications is an active e-mail account. Details about the listserve are attached. Directions for subscribing to Cellnet and for retrieving information may be found below.
 

Laboratory

Please note that some laboratory exercises/demonstrations require the use of animals. We have reduced the number of animals used by modifying procedures and introducing computer simulations into the laboratory. However, certain key objectives of the course cannot be accomplished without utilizing animal tissues. We adhere to Federal guidelines and insist upon humane treatment of animals at all times.

Laboratory Attendance: Attendance in the lab is mandatory; absences will be penalized by deducting 50% of the points from the laboratory assignment that was conducted during the missed lab period and additional points from the discretionary GTA-assigned points. Students who arrive more than 20 min late to lab will not be admitted to lab, their absence will be counted as an unexcused absence, and 20 points will be deducted accordingly. Late assignments will be penalized at a rate of 10% of the total possible points for each day that the assignment is late. These points are taken off before the late assignment is graded.

NOTE: Any student missing three (3) laboratories will automatically fail the course!!

All students must attend the lab section for which they are registered. Students cannot decide to attend alternate lab sections on their own. If an emergency arises, students must obtain permission from Mr. Carpenter or Dr. Compton to attend another section during the week. If you miss a lab due to a university-approved reason, you must make-up the lab at another regularly scheduled time during the week. Contact your GTA, Dr. Compton, or Mr. Carpenter. No make-up labs will be specially scheduled. Only students who are regularly scheduled for and miss a Friday lab will be exempt from this policy.

Snow/Inclement Weather Policy: If a lab period(s) is lost due to a university-declared weather emergency, students must make up the missed lab later in the week according to the policy set out above. Only officially declared university closings will result in students being allowed to attend alternate sessions. Absences by individuals not able to get to campus because of weather situations when the university is open will not be excused.

Important: All submitted work (unless otherwise indicated) is to be the result of your individual effort. The data may be discussed with your peers, but all written work must be your own. Any deviation from this will be considered plagiarism. As an example, you cannot copy sections from the lab manual to include in your reports. All procedures and introductory material should be restated in your own words. If you are in doubt about the acceptability of a group effort, ask your GTA!

A Final Note: The entire staff is dedicated to making this course an enjoyable, worthwhile learning experience. We are very concerned about providing a comfortable atmosphere conducive to learning. We expect you to work hard, but we also realize that you will learn best by asking questions. You, our audience and consumers, should have input into the course and should demand our best efforts. Don't be intimidated or afraid, we are all on your side and stand ready to assist you. Help us to help you by providing questions, useful criticisms, praise, etc.
 
 
 
 

CELLNET LISTSERV

A computer listserv (Cellnet) will be set up on the campus e-mail network in order that students and course staff can communicate with one another. All you will need to receive these important communications is an active e-mail account. Details about the listserve are attached. Directions for subscribing to Cellnet and for retrieving information may be found below.
 

Cellnet-BSCI 230 Online

The BSCI 230 Course Staff presents CELLNET, a computer listserv designed to promote communication between students and staff. The time to subscribe to CELLNET is NOW. CELLNET will be used to communicate information about the course to subscribers and will provide a way for subscribers to pose questions about lectures. Responses to questions will be sent to CELLNET, such that all subscribers will see the question and receive the answer. In addition, CELLNET will provide a convenient way to post lecture outlines and handouts, important information about lab, and other announcements of interest.

Subscribing to Cellnet: The procedure is very simple. First, because you subscribe electronically, you must have a campus computer WAM account or access to e-mail through another provider. If you do not already have an e-mail account, proceed directly to the Computer Science Center, Room 3326. Bring your student ID and current registration card with you. An account will be created for you by one of the counselors.

Do I Have To Have My Own Computer In Order To Be Part Of Cellnet? No. Any member of the UMD community can get a campus computer account. You can go to the computer science center WAM lab to log into your account, and retrieve your CELLNET messages. You do not need to use a WAM account to register to Cellnet.

1. Enter your WAM account or personal e-mail account by using your name and password (do not try to subscribe from an account other than your own, or all of your CELLNET mail will be directed to that account).
2. Once into your account, you must send a mail message to the University's listserv computer, asking it to subscribe you to CELLNET. Your message should be sent to the following address: listserv@umdd.umd.edu
3. Your subscribe message is simply: sub cellnet your name
4. Note: type your actual name.

Send this message electronically, and you will automatically be subscribed to CELLNET. "sub" tells the listserv computer that you want to subscribe, "cellnet" is the name of the listserv your are subscribing to, and your name should follow. That's it! You will then receive a brief message asking you to respond to the computer message to complete the registration process. When officially subscribed, you will receive a brief welcome message and some instructions.

Getting Old Messages From Cellnet: After subscribing to CELLNET, you will get a welcome message that includes some important instructions—e.g., how to retrieve previously sent or deleted messages. DO NOT delete this original message! To get a list of previously sent CELLNET messages, send e-mail to the following address: listserv@umdd.umd.edu. Do not put a subject heading on your memo and do not put any blank lines at the top of it. Your message should read: index cellnet.

You will then receive a listing of these messages. Instructions for retrieving them from the list are contained in the original message from listserv.