PATHOGENIC MICROBIOLOGY


Comparison of Bacterial Exotoxins and Endotoxin


 

 

Exotoxin

 

Endotoxin

 
  Produced by both Gram-positive and Gram-negative bacteria   Produced only by
Gram-negative bacteria
 
  Released from cell   Integral part of cell wall  
  Protein   Lipid A of lipopolysaccharide  
  Many types of exotoxin based
on structure and function
  Only one type of endotoxin  
  Heat labile   Heat stable  
  Specific receptors on
host target cells
  Diverse range of host cells
and systems affected
 
  Specific effects in host   Diverse range of effects in host  
  Toxoids can be made
by treating with formalin
  Toxoids cannot be made  

 

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Copyright © 2000, D.M. Rollins and S.W. Joseph
Revised: September 2003
URL: http://life.umd.edu/classroom/bsci424