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BSCI 440/441

 

Mammalian Physiology

 

Fall 2008

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Lecturer                                  Dr. Sergei Sukharev

                                                sukharev@umd.edu

                                                3216 Bio/Psyc.  Ph 301-405-6923

 

Lab Course Instructor           Dr. Pamela Lanford

BSCI441                                 planford@umd.edu

                                                3218 Bio/Psyc   Ph 301-405-7161

 

Graduate Assistants:

 

Discussions:                 

Carrie Long                         clong4@umd.edu

Miriam Boer                                    mboer@umd.edu

 

 

Important Words of Wisdom (compiled by Dr. W.J.Higgins):

 

"You knew the job was dangerous when you took it, Fred!"

                                    -Super Chicken to his faithful companion, 1967

 

"Personally I am always ready to learn, although I do not always like being taught."

                                                                        - Winston Churchill

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Objectives:

 

1.         Overview major concepts of cell and tissue function as they apply to the entire organism. Study the function and regulation of the organ systems of mammals.

2.         Come to an understanding of these systems through a series of topical discussions.

3.         Enjoy and create a classroom environment conducive to active learning and independent investigation.

 

Prerequisites:  BSCI 230/BSCI 330 and CHEM 233 (as listed in the UMCP Undergraduate Catalog)

 

 

Lecture:          Mon, Wed, and Fri @ 10 A.M. in Bio/Psy 1250

 

Recitation Sessions: once a week:      0101    M 11am –1pm in PLS 1113

begin September 10                              0102    M  2pm – 4pm in PLS 1117    

                                                            0103    M   2pm – 4pm in BPS 1234

                                                            0104    W  11am – 1 pm in PLS 1113

 

Main Text:    Silverthorn DU. (2003, 2004, 2006) Human Physiology. An Intergrated Approach. (2nd ,3d or 4th editions) Pearson/Benjamin Cummings, San Francisco, CA.

 

BSCI 440 “Purple” Manual   is available from the University Book Center in the Stamp Student Union.

 

Other helpful reading:

 

Guyton AC & Hall, JE. Textbook of Medical Physiology, 9th ed. Saunders, Philadelphia, PA, 1996.

 

Ganong WF. Review of Medical Physiology. 19th ed. Appleton & Lange, Stamford, CT, 1999.

 

Lodish H et al. Molecular Cell Biology. 5th ed. W.H. Freeman and Co, NY, 2003.

 

Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 10th ed. Hardman JL, Limbird LE, Molinoff PB, Ruddon RW and Gilman AG, editors. McGraw-Hill, New York, NY, 1996.

 

Stanfield CL & Germann WJ. Principles of Human Physiology. 3d ed, Benjamin Cummings, San Francisco, CA 2007.

 

Takahashi T. Atlas of the Human Body. Harper Perennial, NY, 1994.

 

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Examinations:  Three hourly examinations of 200 points each to be given on:

 

                        - Friday,                      10/10

                        - Monday,                   11/10

                        - Friday,                      12/05

 

These dates are fixed and will not be changed. Sample examinations from previous semesters are available in this package. Please note that you will have two midterm exams before the 10 week drop date with a “W” (November 10).

 

The Final examination (200 points) has been scheduled by the University for Saturday, Dec 20 8:00am-10:00am         

 

                       

 

Regrade Policy:

 

Every effort will be made to ensure that grading of exams will be done fairly and carefully. If you have questions concerning the grading of your exam, after you have checked the posted answer key, you may submit your exam for a regrade. The regrade request should be discussed with the instructor in person during the office hour (or before/after lecture) within 7 days of the return of the exam. We will not consider answers that were misinterpreted by the grader due to sloppy handwriting, poor organization, or incorrect terminology. You must complete all examinations in ink if you wish to discuss a possible grade change with the staff.

 

Make-Up Examinations:

 

            Do not miss an examination for any reason other than a serious medical problem or official university excuse! Please refer to the current edition of the UMCP Undergraduate Catalog for policies and procedures. These regulations (including the requirement for documentation) will be strictly enforced.

 

 

Academic Honesty

The University policy on academic honesty is in effect and will be strictly enforced.

 

 

GRADES:

 

            Examinations = 800 points;       Recitation = 200 points;     Course total =  1000 points

 

            Grade of           A  >  900 points

B  >  800 points

C  >  700 points

D  >  600 points

 

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Your continued enrollment in this course constitutes a binding contract.  Therefore, this grading system is hereby agreed to by all course participants.  Thus there will be no competition among participants, and final course grades need not and will not be discussed/negotiated.  You either have the points or you don't!

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Appointments:

 

            Communication is essential: we must hear your comments, criticisms, questions, etc. There will often be time before and after lecture to answer your questions. Lecturer's office hour is Fri 11-12 am, (Rm 3216, BioPsy Bldg). At other times appointments can be made via email. Mention your name each time so that we will get to know you. Please note that research and teaching schedules usually preclude "drop in" visitors at other times. We are all available via email.


Lecture Schedule

                                                                                          Assigned                     Suggested                        

                                                                                          chapters from             chapters from                  

Topic                                                         Date                Silverthorn                  Guyton

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Prerequisite Materials                                 Previous           1-6,8                           

Introduction: multidimensional

approach in physiology                               9/03                 1-3

Cell, tissue and organ overview,

body compartments                                    9/05                 3, 12                            1-3

 

Epithelia, membrane transport                     9/08                 5                                  4

 

Homeostasis, control                                 

and signaling pathways, hormones               9/12                 6,7, 23                         2               

Basics of neuromuscular physiology             9/17                 8, 12                            4,5-8

Autonomic Nervous System &                    9/26                 11                                60

Pharmacology

 

Blood & Immunity                                      10/03               16, 24                          32,35,36

 

Exam 1                                                      10/10  (regrades accepted through 10/24)

Circulation                                                  10/13                                                   14                         

Heart                                                                      14                                9-11,13

Blood Flow and Regulation                                     15                                14-19

Cardiovascular Disease, Exercise                            15, 25                          20,22                    

 

Respiration                                                 10/26                                                  

            Anatomy & Mechanics                                           17                                37

            Pulmonary Blood Flow                                                                               38                         

            Gas exchange & transport                                       18                                39,40

            Control of Respiration                                                                                 41                         

Exam 2                                                      11/10  (regrades accepted through 11/24)

Renal Function                                            11/12                                                   26             

Anatomy & Processes                                            19                                26

Renal clearance                                                                                          27                                     

Acid-Base & Ion Balance                                       20, 23                          28, 29,30

Exam 3                                                      12/05  (regrades accepted through 12/12)

Digestion                                                    12/08                                                   62

Anatomy                                                                21                                63

Motility & Secretion                                                                                   63,64                    

Digestion & Absorption                                                                              65

 

Energy balance, metabolism and growth                              22                                                 

The Final                                                  12/20 (8-10 am)

 

 

 

 

 

 

 

DISCUSSION (RECITATION) SESSIONS

 

What is a recitation session? This is a time to re-enforce the lecture material through presentations and group discussions. The 2 hr weekly sessions are designed to optimize the learning process and to help you prepare for exams. You will be provided with study questions/problems. You may be called individually to provide answers to a question, and the quality of your explanation will count toward your participation grade. Recitation is the best time to get answers to your questions if something remains unclear.

 

Attendance in recitation is part of your grade. If you miss a session with a legitimate, documented excuse, you may attend another during that same week and check in with your T.A. and the T.A. in that substituted section. Arriving more than 10 minutes late counts as a missed recitation!

 

Each recitation session will begin with a brief introduction given by the TA. It will be followed by student presentations (20 min + 10 min questions/discussion). Your participation in the discussions is expected. Then you will have 40-45 min to discuss study questions.

 

Presentations are essentially mini-research topics which will be assigned/chosen to groups of two, who will be given 20 min to deliver results of their study of a certain system, phenomenon, mechanism or disease with appropriate background. The reading for these presentations include the main text, Guyton’s Physiology, Ganong’s Review of Medical Physiology, Goodman&Gilman’s “The Pharmacological Basis of Therapeutics”, or selected reviews in specialized journals (optional). The presenters should strive to become "experts" in that particular topic. Each group of two is expected to give one presentations during the semester.  Students may use the blackboard, transparencies or PowerPoint as an aid; however, no special props are necessary.

 

Additionally, study questions taken either from the Detailed Syllabus or from previous exams will be discussed. Before each mid-term exam you will be given a 15 min (20 pt) quiz, which will help you to assess your readiness.

 

The computer work may include exercises with the 7 System CD.

 

Grading: Attendance and participation in class discussion as determined by your TA:  50 pts.

                  Presentations, answers:                                                                                     60 pts

                  Announced quizzes (3):                                                                                     90 pts                   

 

To do well in this course you should:

 

 - Attend EVERY lecture and recitation session; organize your lecture notes; read assigned chapters paying most attention to figures and major concepts first, then gather all necessary details; practice quantitative problems.  It really helps if you form a small study group.                                                                                

 

We expect you to work hard; but you, our audience, should have input into the course and should demand our best efforts.  Help us to help you by providing questions, criticisms, praise, etc.