HOMEOSTASIS
&
PERIPHERAL NERVOUS SYSTEM
Chapters 1 & 6 of Your Text
Recitations and Labs begin 1 February
Recitations meet in PLS 1121 & Labs in ZOP 2223
The MAMPHYS Listserve:
Why aren’t YOU on it?!
Design a system to maintain homeostasis:
- Sensor
- Comparator & Reference
- "Wires"
- Effector
- Output
CLOSED LOOP, NEGATIVE FEEDBACK SYSTEM
‘Nerve’ & Neuron’
Related Good Stuff
Goldman Equation
Hyperpolarization
Depolarization
Permeability vs. Conductance
(P vs. g)
Neurotransmiiters & Receptors
Exocytosis
Receptors
[NT] + R <------> [NT]*R
NT removal
epsp & ipsp
Post Synaptic Events:
- Agonist
- Antagonist (Blocker)
ADRENERGIC RECEPTORS
a1
- Excitatory
a2
- Inhibitory
b1 -
Excitatory
b2
- Inhibitory
CHOLINERGIC RECEPTORS
NICOTINIC
MUSCARINIC
Nervous System
CNS
Brain & Spinal Column
PNS
Afferent - Sensory
Efferent - Motor
Efferent Nervous System
(see course manual)
Somatic
Autonomic
Parasympathetic
Sympathetic
ADRENERGIC RECEPTORS:
a1
- Excitatory
a2
- Inhibitory
b1
- Excitatory
b2
- Inhibitory
CHOLINERGIC RECEPTORS:
NICOTINIC
MUSCARINIC
SOMATIC vs. AUTONOMIC
STRUCTURES INNERVATED
MODE OF ACTION
EFFECT OF DENERVATION
SYMPATHETIC vs. PARASYMPATHETIC
OUTFLOWS FROM SPINAL CORD
NEUROTRANSMITTERS
DEGREE OF BRANCHING
Preganglionic to Postganglionic Ratio
ACTIONS ON EFFECTORS
SYMPATHETIC ACTIONS:
Fight or Flight!!!
HEART RATE = +
HEART BEAT STRENGTH = +
BLOOD FLOW TO SKELETAL MUSCLE = +
BRONCHIOLE DIAMETER = +
BLOOD FLOW TO INTESTINE = -
BLOOD GLUCOSE = +
INTESTINAL ACTIVITY = -
PUPIL DIAMETER = +
SWEAT GLANDS = +
ANS PHARMACOLOGY
SYMPATHETIC RECEPTOR EXCEPTIONS
Sweat glands: ACh onto muscarinic (Excite)
Some blood vessels to skeletal muscles: ACh onto muscarinic (Inhibitory)
Adrenal Medulla
BLOOD VESSELS RECEIVE ONLY SYMPATHETIC INNERVATION!
PARASYMPATHETIC ACTIONS
IMAGINE: sleeping in a chair after a good meal!
Presynaptic Inhibition
