ANS PHARMACOLOGY

ANS PHARMACOLOGY

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Adrenergic Receptors

a1 = excitatory (predict)
b1 = excitatory (heart ONLY)
a2= inhibitory (gut & presynap)
b2 = inhibitory (predict)

SPECIFIC THINGS TO REMEMBER:

BLOOD VESSELS

CONSTRICT = EXCITATORY

(a1 receptor)

DILATE = INHIBITORY

(b2 or muscarinic receptor)

PUPIL OF EYE

SYMP =NE ON a1 for dilation

PARASYMP = ACh on MUSCARINIC FOR CONSTRICTION

PRESYNAPTIC OR AXONAL AGENTS:

PROCAINE (NOVOCAINE)

TETRODOTOXIN (TTX)*

BATRACHATOXIN*

BOTULINUS TOXIN

MUSCARINIC AGONISTS
(parasympathomimetic)

ACh*

MUSCARINE*

PILOCARPINE*

FURMETHIDE

MUSCARINIC ANTAGONISTS

ATROPINE *(Belladonna)

SCOPALOMINE

NICOTINIC AGONISTS

ACh*

NICOTINE*

DMPP

(1,1-dimethyl-4-phenylpiperazinium)

NICOTINIC ANTAGONISTS

HEXAMETHONIUM (C6)*

(AT ANS GANGLIA)

d-TUBOCURARINE*

(CURARE)

ANTI-CHOLINESTERASES
REVERSIBLE & COMPETITIVE:

ESERINE*

PROSTIGMINE

ANTI-CHOLINESTERASES
IRREVERSIBLE &

NON-COMPETITIVE:

ORGANOPHOSPAHTES (DFPs)

-TABUN, SARIN, SOMAN

-MALATHION & PARATHION

ADRENERGIC a AGONISTS

EPINEPHRINE*

NOREPINEPHRINE*

PHENYLEPHRINE*

PSUEDOEPHEDRINE

PHENYLPROPANOLAMINE

Adrenergic a Antagonists

PHENTOLAMINE*

PHENOXYBENZAMINE*

PRAZOSIN

Adrenergic b Agonsists

EPINEPHRINE*

ISOPROTERENOL*

NOREPINEPHRINE (weak at b2)*

Adrenergic b Antagonist

PROPRANOLOL*

Synthesis of NE

EPI & NE SYNTHESIS INHIBITORs:

a - methyl - p - tyrosine

a - methyl - DOPA (ALDOMET)

OTHER ADRENERGIC AGENTS OF INTEREST

(METH)AMPHETAMINE
EPHEDRINE
RESERPINE

HISTAMINERGIC AGENTS

(H1 & H2 AGONIST)

- HISTAMINE*

(H1 & H2 ANTAGONIST)

- CHLORPHENIRAMINE

- DIPHENHYDRAMINE