Discussion Topic Readings Fall 2002

October 23 (André Mignault)

Budiansky, S. 2002. Creatures of our own making. Science, 298(5591): 80-86.

Holt, R.A., G.M. Subramanian, A. Halpern, et al., et al., et al. 2002. The genome sequence of the malaria mosquito Anopheles gambiae. Science, 298(5591): 129-149.

Oct. 30 (Razvan) - Arabidopsis - Gene finding

Nov. 6 (Xiaoqin) - Functional Genomics

Dec. 2 (Lixin) - Promoters and regulatory elements

Kolell, K. J., and Crawford, D. L. 2002. Evolution of Sp transcription factors. Mol. Biol. Evol. 19:216-222.

Dec. 4 (Lisa Pfeifer) - Johnson et al. is the primary paper, but you may want to look at Bailey for additional information.

Johnson, M.E. 2001. Positive selection of a gene family during the emergence of humans and African apes. Nature 413:514-519.

Bailey, J.A., et al., 2002. Recent segmental duplications in the human genome. Science 297:1003-1007

Dec. 9 (Eva Claire)

Goff et al. 2002. A Draft Sequence of the Rice Genome (Oryza sativa L. ssp. japnonica) Science 296: 92-100.

http://www.enn.com/news/enn-stories/2001/04/04042001/rice_42868.asp?site=email

http://www.scidev.net/frame3.asp?id=0506200218140534&t=N&c=1&r=1

Dec. 11 (Mike) - We will compare the following two papers (Ewing and Green, 2000, and Liang et al., 2000), both of which can't be right. The additional papers are to provide context and background.

Ewing, B.and Green, P. 2000. Analysis of expressed sequence tags indicates 35,000 human genes. Nature Genetics 25:232-

Liang, F., et al. 2000. Gene index analysis of human genome estimates approximately 120,000 genes. Nature Genetics 25:239-.

Nature Genetics Editorial Staff. 2000. The nature of the number. Nature Genetics 25:127-128.

Aparicio, S.A.J.R. 2000. How to count... human genes. Nature Genetics 25:129-.