Fig. 8. Folding pattern of yeast VDAC in a phospholipid membrane. This pattern illustrates the transmembrane strands proposed to form the walls of the pore of the VDAC channel. The extended b strands would be hydrogen-bonded together and to the a helix forming a cylindrical structure. The boxed residues are sites that affect the ion selectivity of the channel. Circled residues are sites that had no effect on ion selectivity.