TCV Laboratory


We are studying cap-independent translation of three viruses: Turnip crinkle virus (TCV), Pea enation mosaic virus (PEMV) and Saguaro cactus virus (SCV). All three viruses contain 3' cap-independent translational enhancers in their 3' regions that represent new paradigms for translation. Our lab uses state-of-the-art RNA structure mapping (low and high through put), single-molecule biophysical techniques such as optical tweezers, and genetic manipulations to elucidate how 3' proximal ribosomal binding elements enhance translation.

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Questions about the lab can be e-mailed to:  Anne Simon

Designed by Brian Scott, 1997
Maintained by the Simon Lab