Macrophages and Host Defense Lab

The Laboratory of Macrophages and Host Defense
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Shanjin Cao, M.D. (1987); Ph.D. (1999)

Present position:  Research Assistant Professor

Previous position: Postdoctoral associate, Weill Medical College of Cornell University,  New York, NY

PhD: Beijing Medical University, Beijing, China

Research Interest: Macrophage biology and gene regulation


Publications: 2008-2002


  1. Yoichiro Homma, Shanjin Cao, Xiaoyan Shi, Xiaojing Ma. The Th2 transcription factor c-Maf inhibits IL-12p35 gene expression in activated macrophages by targeting NF-B nuclear translocation. J. Interferon Cytokine Research. 2007; 27(9):799-808. (co-first author) PubMed

  2. Shanjin Cao, Xia Zhang, Justin P. Edwards, and David M. Mosser. NF-B1 (p50) Homodimers Differentially Regulate Pro- and Anti-inflammatory Cytokines in Macrophages. J Biol Chem 2006, 281: 26041-26050. PubMed

  3. Cao, SJ., Zhang, X., Edwards, J.P., and Mosser, D.M. 2006.  NF-kappaB1 (p50) homodimer differentially regulate pro- and anti-inflammatory cytokines in macrophages.  J. Biological Chemistry. In Press.

  4. Shanjin Cao, Jianguo Liu, Lihua Song, and Xiaojing Ma. The proto-oncogene c-Maf is an essential transcription factor for interleukin-10 gene expression in macrophages. The Journal of Immunology, 2005. 174:3484-3492.
  5. Jianguo Liu, Shanjin Cao, Sunjung Kim, Elaine Y. Chung, Yoichiro Homma, Xiuqin Guan, Violeta Jimenez, and Xiaojing Ma. Interleukin-12: an update on its immunological activities, signaling and regulation of gene expression. Current Immunology Review, 2005 in press.
  6. Shanjin Cao, Zhaoying Xiang, and Xiaojing Ma. Global gene expression profiling in interleukin-12-induced activation of CD8+ cytotoxic T lymphocytes against mouse mammary carcinoma. Cellular & Molecular Immunology, 2004, 1(5):357-366. [Full Text] Archive
  7. Xiaoyan Shi, Shanjin Cao, Maki Mitsuhashi, Zhaoying Xiang, and Xiaojing Ma. Genome-Wide Analysis of Molecular Changes in IL-12-Induced Control of Mammary Carcinoma via IFN--Independent Mechanisms. The Journal of Immunology, 2004, 172: 4111–4122. PubMed Abstract
  8. Maki Mitsuhashi, Jianguo Liu, Shanjin Cao, Xiaoyan Shi, and Xiaojing Ma. Regulation of interleukin-12 gene expression and its anti-tumor activities by prostaglandin E2 derived from mammary carcinomas. J. Leukoc. Biol 2004; 76(2): 322-332. PubMed Abstract
  9. Heng Cui, Xiaohong Chang, Bei Liu, Jie Feng, Yi Li, Xue Ye, Shanjin Cao, Tianyun Fu, Yu Yao, HQ Li, and Hennian Qian. The anti-tumor immune responses induced by a fusion protein of ovarian carcinoma anti-idiotypic antibody 6B11ScFv and murine GM-CSF in BALB/c mice. Int J Gynecol Cancer 2004, 14, 234-241. PubMed Abstract
  10. Jianguo Liu, Shanjin Cao, Lisa M. Herman and Xiaojing Ma. Regulation of interferon- primed interleukin-12 production and tumor surveillance by interferon regulatory factor-1. J Exp Med 2003; 10: 1265-1276. PubMed Abstract
  11. Xiaohong Chang, Heng Cui, Jie Fang, Yi Li, Bei Liu, Shanjn Cao, Yexia Cheng, Henian Qian. Preparation of humanized ovarian carcinoma anti-idiotypic minibody. Hybrid Hybridomics 2003, 22(2): 109-115. PubMed Abstract
  12. Shanjin Cao, Jianguo Liu, Marta Chesi, Peter Leif Bergsagel, I-Cheng Ho, Raymond P. Donnelly, and Xiaojing Ma. Differential regulation of IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor c-Maf fibrosarcoma. The Journal of Immunology 2002; 169:5715-5725. PubMed Abstract
  13. He-nian Qian, Guang-zhi Liu, Shanjin Cao, Jie Feng and Xue Ye. The experimental study of ovarian carcinoma vaccine modified by human B7-1 and IFN- genes. International Journal of Gynecology Cancer 2002; 12:80-85. PubMed  Abstract

Research Summery:

We are interested in the regulation of IL-10 production by the Type II activated macrophage.  The regulation of IL-10 transcription and the transcription factors that drive gene expression is a focus of current studies.  A variety of techniques, including siRNA, promoter reporter genes, and dominant negatives are being brought to bear on this problem.  Macrophage biology and immune gene transcription regulation.