The Laboratory of Macrophages and Host Defense

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Publications 2005-2014


Miles, S.A., Conrad, S.M., Alves, R.G., Jeronimo, S.M.B., and Mosser, D.M. 2005.  A role for immune complexes during infection with the intracellular pathogen, Leishmania spp.  J. Experimental Medicine  201:747-754.

Goncalves, R., Vieira, E.R., Melo, M.N., Gollob, K.J., Mosser, D.M. and Tafuri, W.L.  2005.  A sensitive flow cytometric methodology for studying the binding of L. chagasi to canine peritoneal macrophages.  BMC Infect Diseases 5:39-49.

Lucas, M., Zhang, X., Prasanna, V. and Mosser, D.M. 2005.  ERK activation following macrophage FcgR ligation leads to chromatin modifications at the IL-10 locus.  J. Immunology 175:469-77.

Zhang, X., Edwards, J.P., and Mosser, D.M. 2006.  Dynamic and transient remodeling of the macrophage IL-10 promoter during transcription.  J. Immunology 177:1282-88.

Edwards, J.P., Zhang, X., Frauwirth, K.A., and Mosser, D.M. 2006.  Biochemical and Functional Characterization of Three Activated Macrophage Populations. J. Leukocyte Biology 80:1298-1307.

Cao, S. Zhang, X. Edwards, J.P. and Mosser, D.M. 2006.  NF-kB1 homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages.  J. Biological Chemistry 281:26041-50.

Miles, S.A. and Mosser, D.M. 2007 Avoidance of innate immune mechanisms by the protozoan parasite, Leishmania spp. in Protozoans in Macrophages eds Denkers and Gazinelli, Landes Biosciences. pp118-129.

Conrad, S.M., Strauss-Ayali, D., Field, A.E., Mack, M. and Mosser, D.M. 2007.  Leishmania-derived murine Monocyte Chemoattractant Protein 1 enhances the recruitment of a restrictive population of CC chemokine receptor 2-positive macrophages.  Infection and Immunity 75:653-65.

Zhang, X., Edwards, JP., and Mosser, D.M.  2007. "The expression of exogenous genes in macrophages: obstacles and opportunities" in Methods in Molecular Biology Human Press,  Ed. N.E. Reiner (in press).

Strauss-Ayali, D., Conrad, S.M. and Mosser, D.M. 2007.  Monocyte subpopulations and their differentiation patterns during infection.  J. Leukocyte Biol 82:244-52.

Yang, Z. Mosser, D.M. and Zhang, X. 2007.  Activation of the MAPK, ERK following Leishmania amazonensis infection of macrophages.  J. Immunology 178:1077-85.

Field, A.E. , Wagage, S. Conrad, S.M. and Mosser, D.M. 2007.  Reduced pathology following infection with transgenic Leishmania major expressing murine CD40 ligand. Infection and Immunity 75:3140-49.

Marbach-Ad, G., Briken, V., Frauwirth, K., Gao, L.Y., Hutcheson, S.W., Joseph, S.W.,  Mosser, D.M., Parent, B., Shields, P., Song, W., Stein, D.C., Swanson, K., Thompson, K.V., Yuan, R. and  Smith, A.C. 2007.  A Faculty Team Works to Create Content Linkages among Various Courses to Increase Meaningful Learning of Targeted Concepts of Microbiology.  CBE Life Sci Educ 6:155–162.

Park, J.Y., Farrance, I.K., Fenty, N.M., Hagberg, J.M., Roth, S.M., Mosser, D.M., Wang, M.Q., Jo, H., Okazaki, T., Brant. S.R., Brown, M.D. 2007. Am. J. Heart. Circ. Physiol. 293:2320-27.

Zhang, X. and Mosser, D.M.  2008.  Macrophage activation by endogenous danger signals.  J. Pathol. 214:161-78.

Bonfield, T.L., Thomassen, M.J., Farver, C.F., Abraham, S. Koloze, M.T., Zhang, X., Mosser, D.M. and Culver, D.A. 2008.  J. Immunology 181:235-42.

Zhang, X. Goncalves, R. and Mosser, D.M. 2008. The isolation and characterization of murine macrophages. Current Protocols Immunology. Unit 14.1

Mosser, D.M. and Zhang, X. 2008. Activation of murine macrophages.  Current Protocols Immunology. Unit 14.2

Mosser, D.M. and Zhang, X. 2008.  IL-10: New perspectives on an old cytokine.  Immunological Reviews. 226:205-218

Mosser, D.M. and Edwards, J. P. 2008.  Exploring the full spectrum of macrophage activation.  Nature Reviews Immunology. 8:958-969.

Marbach-Ad, G. Briken, V., El-Sayed, N., Frauwirth, K. Fredericksen, B., Hutcheson, S., Gao, L., Joseph, S., Lee, V., McIver, K. S., Mosser, D. M., Quimby, B. B., Shields, P. Song, W. Stein, D. C., Yuan, R. T. and Smith, A. C.  2009. Assessing Student Understanding of Host Pathogen Interactions Using a Concept Inventory. J. Microbiol. Biol. Edu. 10:43-50.

Cates, E.A., Connor, E.E., Mosser, D.M. and Bannerman, D.D. 2009.  Functional characterization of bovine TIRAP and MyD88 in mediating bacterial lipopolysaccharide-induced endothelial NF-kB activation and apoptosis. Comp. Immunol. Microbiol. Infect. Dis. 32:477-90.

Edwards, J.P. Zhang, X. and Mosser, D.M. 2009.  The expression of heparin-binding epidermal growth factor-like growth factor by regulatory macrophages.  J. Immunology 182:1929-39.

Zhang, X. Edwards, J.P. and Mosser, D.M. 2009. The expression of exogenous genes in macrophages: obstacles and opportunities. Methods in Mol. Biol.  531:123-43.

Gallo, P. Goncalves, R. and Mosser, D.M. 2010.  The influence of IgG Density on Phagocytosis and IL-10 Production following Macrophage Fc (gamma) Receptor Cross-linking.  Immunol Letters 133:70-7.

Halstead, S.A. Mahalingham, S. Marovich, M. A. Ubol, S. and Mosser, D.M.  2010.  Intrinsic antibody enhancement of infection in macrophages: disease regulation by immune complexes.  Lancet Infect. Dis. 10:712-22.

Marbach-Ad G. McAdams, K.C. Benson, S. Briken, V. Cathcart, L. Chase, M. El-Sayed, N. Frauwirth, K. Fredericksen, B. Joseph, S. Lee, V. McIver, K. Mosser, D.M. Quimby, B.B. Shields, P. Song, W. Stein, D.C. Stewart, R. Thompson, K.V. Smith, A.C. 2010. A model for using a concept inventory as a tool for students’ assessment and faculty professional development. CBE Life Sci Educ. 9:408-16.

Reis M.L. Ferreira, V.M. Zhang, X. Goncalves, R. Vieira L.Q. Tafuri, W.L. Mosser, D.M. and Tafuri, W.L. 2010. Murine immune responses induced by Leishmania major during the implantation of paraffin tablets.  Virchows Arch. 457:609-18.

Yang, Z. Zhang, X. Darrah, P.A. and Mosser, D.M. 2010. The regulation of Th1 responses by the p38 MAPK. J. Immunol. 185:6205-13.

Liu, X. Lu, L. Yang, Z. Palaniyandi, S. Zeng, R. Gao, L.Y. Mosser, D.M. Roopenian, D.C. and Zhu, X. 2011.  The neonatal FcR mediated presentation of immune complexed antigen in associated with endosomal and phagosomal pH and antigan stability in macrophages and dendritic cells.  J. Immunol. 186:4674-86.

Yang, Z. Kong, B. Mosser, D.M. and Zhang, X. 2011.  TLRs, macrophages and NK cells: Our understanding of their function in the uterous and ovary. Int. Immunopharmacol. 11:1442-50.

Goncalves, R. Zhang, X. Cohen, H. Debrabant, A. and Mosser, D.M. 2011.  Platelet activation attracts a subpopulation of effector monocytes to sites of L. major infection.  J. Exp. Med. 208:1253-65.

Fleming,B.D. and Mosser, D.M. 2011 Regulatory macrophages:  Setting the threshold for therapy.  Eur. J. Immunol.  41:2498-502.

Briken, V. and Mosser, D.M. 2011.  Switching on arginase in M2 macrophages.  J. Leuk. Biol. 90:839-41.

Mosser, D.M. and Zhang, X.  2011. Measuring opsonic phagocytosis via Fcγ receptors and complement receptors on macrophages.  Curr. Protoc. Immunol. XChapter 14, Unit 14.27

Cohen HB, Briggs KT, Marino JP, Ravid K, Robson SC, Mosser, DM.  2013.  TLR stimulation initiates a CD39-based autoregulatory mechanism that limits macrophage inflammatory responses.  Blood 122(11):1935-45.

Cohen HB, Mosser, DM.  2013.  Extrinsic and intrinsic control of macrophage inflammatory responses.  J Leukoc Biol. 94(5):913-9.

Sousa LM, Carneiro MB, Resende ME, Martins LS, Dos Santos LM, Vaz LG, Mello PS, Mosser, DM, Oliveira MA, Vieira LQ.   2014.  Neutrophils have a protective role during early stages of Leishmania amazonensis infection in BALB/c mice.  Parasite Immunol. 36(1):13-31.

Suresh R, Mosser, DM.   2014.  Pattern recognition receptors in innate immunity, host defense, and immunopathology.   Adv Physiol Educ. 37(4):284-91.

Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, Locati M, Mantovani A, Martinez FO, Mege JL, Mosser, DM Natoli G, Saeij JP, Schultze JL, Shirey KA, Sica A, Suttles J, Udalova I, van Ginderachter JA, Vogel SN, Wynn TA.   2014.  Macrophage activation and polarization: nomenclature and experimental guidelines.   Immunity. 41(1):14-20.

Cohen HB, Mosser, DM.   2014.  Cardiac macrophages: how to mend a broken heart.   Immunity. 40(1):3-5.