MICB 688L

Advanced Cell Biology

Spring 2005
 
Prof. Heven Sze
Tu, Th 9:30-10:45 pm
 
Hsze@umd.edu
HJ Patt Rm 1229
 
HJ Patt, 3237
Tu, Th p.m. by appointment
Course       Proposal Outline          Journal Presentation         Websites 
Lect.
Date
Topic
Alberts
Lodish
         
1
Jan. 27
Introduction to course; universal features of cells
chap.1
1,3
2
Feb 1
Review of techniques used in Cell Biology
8, 9, 10
2,3,5
3
Feb. 3
Membranes & Transport- concepts and methods 
11
15
4
8
Pumps, cotransporters, channels
11
15, 21-3
5
10
Journal: J1, J1-Dtr1p 
    
6
15
Journal discussion. J2, J2-AQY1
 
7
17
Protein synthesis and sorting: Concepts and methods
12
17.1
8
22
Mitochondria; Nuclear transport
12
11.4
9
24
Journal J3- snow day. J3-Yi-Exp5, J3-Lund-Exp5
12
 
10
Mar 1
Journal discussion. J4-Sesaki, J4-Meeusen
    
11
Mar.3
Methods- rev.  Biosynthesis-secretory pathways
12 
17.3-5, 21.6-8,
12
8
Vesicular transport: budding, docking, fusion
13
17.0-10
21. 33
13
10

Journal discussion: J5-Rab organizer, J5-targettingRab, J5-Rab_effector
(Take home exam distributed- due 3/15)
14
15

Exam I

   
15
17
Discussion/journal. J-6-Vac fusion, J6-fertiliz-exo-endo
 
 
16
22, 24
Spring break
 
 
 
29
 Discussion -examI
 
 
17
31
 Signal transduction
 
18
Apr. 5
Guest speaker Dr. Hamza. Golgi & Mitosis
18
13
19
7
Golgi & Mitosis, Journal discussion -
 
 
20
12
Journal discussion - Signaling pTyr , LUMIER-network
(Proposal Draft/Outline Due- 2 page limit)
16
18, 19
21
14
Journal discussion -Cell death Autophagy
22
19
Cytoskeleton
 16
 
23
21
Journals Ridley-Rho Rac-actin
 
 
24
26
Guest speaker-Dr. Gao. Cellular mechanism of Mycobacteria pathogenesis: phagocytosis
    
25
28
Pathogenesis- Journal Mt-phagosome Legionaire-Rab
    
26
May 3
Journal discussion - cell cycle
 
 
27
5
Journal discussion - Ubiquitin
 
 
28
10
Exam II- proposal presentation 10 min/each
 
 
29
12
Last day of class - Proposal presentation 10 min/ea
 
 

May 17, Tuesday: 4 p.m. Final proposal due.

Text: Molecular Biology of the Cell, 4th Edition. Garland Science
Alberts, Johnson, Lewis, Raff, Roberts, Walter (2002)

Course Website: http://www.life.umd.edu/classroom/mocb639/